Dimethyl Sulfoxide → 4-(2-chloropyridin-3-yl)-N-methylpyridin-2-amine

HRID 593919ノート

反応式

HRID 593919 の反応式
[Cl:1][C:2]1[C:7]([C:8]2[CH:13]=[CH:12][N:11]=[C:10](F)[CH:9]=2)=[CH:6][CH:5]=[CH:4][N:3]=1.Cl.[CH3:16][NH2:17].C([O-])([O-])=O.[K+].[K+].CS(C)=O>O>[Cl:1][C:2]1[C:7]([C:8]2[CH:13]=[CH:12][N:11]=[C:10]([NH:17][CH3:16])[CH:9]=2)=[CH:6][CH:5]=[CH:4][N:3]=1

参加物

6

反応物 4

HCID 679Dimethyl SulfoxideHCID 11430Potassium CarbonateHCID 6364545Methylamine hydrochlorideHCID 161089822-Chloro-2'-fluoro-3,4'-bipyridine

生成物 1

HCID 161089834-(2-chloropyridin-3-yl)-N-methylpyridin-2-amine

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
80 °C

実験手順

2-chloro-2′-fluoro-[3,4′]bipyridinyl (5.30 g, 25.4 mmol), methylamine hydrochloride (9.00 g, 133 mmol) and K2CO3 (28.1 g, 203 mmol) was added DMSO (70 mL). The mixture was heated overnight at 80° C. in a sealed tube. The cooled mixture was diluted with water (300 mL) and the resulting solid was filtered, washed with water and dried to yield (2-chloro-[3,4′]bipyridinyl-2′-yl)-methyl-amine. MS m/z=220 [M+1]+. Calc'd for C11H10ClN3: 219.68.

後処理

  1. filtrationthe resulting solid was filtered
  2. washwashed with water
  3. customdried

出典と根拠

ORDレコード
ord-5715593941cf40f2aeb4f18dd7afe25a
出典データセット
uspto-grants-2016_01
特許番号
US09242961B2

反応ノート

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