関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Morpholine | HCID 8083 | — |
| 反応物 | 4-(Benzyloxy)-2,6-dichloropyridine | HCID 58209046 | — |
| 溶媒 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 生成物 | 4-(4-(Benzyloxy)-6-chloropyridin-2-yl)morpholine | HCID 90409947 | — |
反応手順
A mixture of 4-(benzyloxy)-2,6-dichloropyridine (1.0 equiv.) and morpholine (1.2 equiv.) in NMP (2 M) were heated to 130° C. for 1 h in the microwave. The reaction mixture was partitioned between water and EtOAc. The organic phase was washed with brine and dried over sodium sulfate. The solution was concentrated and dried under vacuo to give crude 4-(4-(benzyloxy)-6-chloropyridin-2-yl)morpholine and was used in the next step without further purification. LCMS (m/z) (M+H)=305.0, Rt=1.10 min.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US09242969B2 |
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| 出典データセット | uspto-grants-2016_01 |
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| ORD ID | ord-c2eedfd2ac7642efb0746d80526589d0 |
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| 出典メモ | uspto-grants-2016_01 |
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