反应详情

温度

130 °C

A mixture of 4-(benzyloxy)-2,6-dichloropyridine (1.0 equiv.) and morpholine (1.2 equiv.) in NMP (2 M) were heated to 130° C. for 1 h in the microwave. The reaction mixture was partitioned between water and EtOAc. The organic phase was washed with brine and dried over sodium sulfate. The solution was concentrated and dried under vacuo to give crude 4-(4-(benzyloxy)-6-chloropyridin-2-yl)morpholine and was used in the next step without further purification. LCMS (m/z) (M+H)=305.0, Rt=1.10 min.

1. customThe reaction mixture was partitioned between water and EtOAc
2. washThe organic phase was washed with brine
3. dry with materialdried over sodium sulfate
4. concentrationThe solution was concentrated
5. customdried under vacuo