4-Fluorobenzenesulfonyl chloride → HCID 89875926、化合物

HRID 594117

反応式

HRID 594117 の反応式
[CH:1]([C:4]1[CH:5]=[CH:6][C:7]([NH2:10])=[N:8][CH:9]=1)([CH3:3])[CH3:2].[F:11][C:12]1[CH:17]=[CH:16][C:15]([S:18](Cl)(=[O:20])=[O:19])=[CH:14][CH:13]=1>N1C=CC=CC=1>[F:11][C:12]1[CH:17]=[CH:16][C:15]([S:18]([NH:10][C:7]2[CH:6]=[CH:5][C:4]([CH:1]([CH3:3])[CH3:2])=[CH:9][N:8]=2)(=[O:20])=[O:19])=[CH:14][CH:13]=1

参加物

4

反応物 2

HCID 95884-Fluorobenzenesulfonyl chlorideHCID 179858055-(Propan-2-yl)pyridin-2-amine

生成物 1

HCID 89875926HCID 89875926、化合物収率 66.4%

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

5-isopropylpyridin-2-amine (300 mg, 2.20 mmol) and 4-fluorobenzene-1-sulfonyl chloride (557 mg, 2.86 mmol) were dissolved in pyridine (3 mL) and left to stand overnight. The reaction mixture was concentrated in vacuo and the crude product extracted to the organic phase of an acidic workup between ethyl acetate and 5% citric acid. The organic phase was passed through a hydrophobic frit and concentrated in vacuo to give the title compound (430 mg). LCMS (2 min, formic) Rt 0.90 min, m/z (ES+) 295 (M+H).

後処理

  1. waitleft
  2. concentrationThe reaction mixture was concentrated in vacuo
  3. extractionthe crude product extracted to the organic phase of an acidic workup between ethyl acetate and 5% citric acid
  4. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-cb801e81b9cb49548a2316c7451a05f4
出典データセット
uspto-grants-2016_01
特許番号
US09242972B2

関連ノート

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