Styrene-4-sulfonyl chloride → HCID 89876040、化合物

HRID 594141

反応式

HRID 594141 の反応式
[CH:1]([C:4]1[CH:5]=[CH:6][C:7]([NH2:10])=[N:8][CH:9]=1)([CH3:3])[CH3:2].[CH:11]([C:13]1[CH:18]=[CH:17][C:16]([S:19](Cl)(=[O:21])=[O:20])=[CH:15][CH:14]=1)=[CH2:12]>N1C=CC=CC=1>[CH:1]([C:4]1[CH:5]=[CH:6][C:7]([NH:10][S:19]([C:16]2[CH:17]=[CH:18][C:13]([CH:11]=[CH2:12])=[CH:14][CH:15]=2)(=[O:21])=[O:20])=[N:8][CH:9]=1)([CH3:3])[CH3:2]

参加物

4

反応物 2

HCID 9855777Styrene-4-sulfonyl chlorideHCID 179858055-(Propan-2-yl)pyridin-2-amine

生成物 1

HCID 89876040HCID 89876040、化合物

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

To a solution of 5-isopropylpyridin-2-amine (400 mg, 2.94 mmol) in pyridine (5 mL), stirred at room temperature, was added 4-vinylbenzene-1-sulfonyl chloride (760 mg, 3.75 mmol). The reaction mixture was stirred for 30 minutes then stood overnight. The solvent was evaporated in vacuo and the crude sample purified by normal phase chromatography on silica (Si) (0-50% ethyl acetate-cyclohexane gradient). The appropriate fractions were combined and evaporated in vacuo to give the title product, 670 mg, as an off-white solid. LCMS (2 min, formic) Rt 0.98 min, m/z (ES+) 303 (M+H).

後処理

  1. waitthen stood overnight
  2. customThe solvent was evaporated in vacuo
  3. customthe crude sample purified by normal phase chromatography on silica (Si) (0-50% ethyl acetate-cyclohexane gradient)
  4. customevaporated in vacuo

出典と根拠

ORDレコード
ord-01faa48f2f634de2a97d950c83df31df
出典データセット
uspto-grants-2016_01
特許番号
US09242972B2

関連ノート

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