Sodium Carbonate → (S)-2-(3-aminophenyl)-7-methoxy-8-(3-((S)-7-methoxy-2-(4-methoxyphenyl)-5,11-dioxo-10-((2-(trimethylsilyl)ethoxy)methyl)-5,10,11,11a-tetrahydro-1H-pyrrolo[2,1-c][1,4]benzodiazepin-8-yloxy)propyloxy)-10((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11(10H,11aH)-dione

反応式

[NH2:1][C:2]1[CH:3]=[C:4](B(O)O)[CH:5]=[CH:6][CH:7]=1.[CH3:11][O:12][C:13]1[CH:18]=[CH:17][C:16]([C:19]2[CH2:20][C@@H:21]3[N:27]([CH:28]=2)[C:26](=[O:29])[C:25]2[CH:30]=[C:31]([O:72][CH3:73])[C:32]([O:34][CH2:35][CH2:36][CH2:37][O:38][C:39]4[C:69]([O:70][CH3:71])=[CH:68][C:42]5[C:43](=[O:67])[N:44]6[CH:59]=[C:58](S(C(F)(F)F)(=O)=O)[CH2:57][C@H:45]6[C:46](=[O:56])[N:47]([CH2:48][O:49][CH2:50][CH2:51][Si:52]([CH3:55])([CH3:54])[CH3:53])[C:41]=5[CH:40]=4)=[CH:33][C:24]=2[N:23]([CH2:74][O:75][CH2:76][CH2:77][Si:78]([CH3:81])([CH3:80])[CH3:79])[C:22]3=[O:82])=[CH:15][CH:14]=1.C(=O)([O-])[O-].[Na+].[Na+]>C1(C)C=CC=CC=1.C(O)C.O>[NH2:1][C:2]1[CH:3]=[C:4]([C:58]2[CH2:57][C@@H:45]3[N:44]([CH:59]=2)[C:43](=[O:67])[C:42]2[CH:68]=[C:69]([O:70][CH3:71])[C:39]([O:38][CH2:37][CH2:36][CH2:35][O:34][C:32]4[C:31]([O:72][CH3:73])=[CH:30][C:25]5[C:26](=[O:29])[N:27]6[CH:28]=[C:19]([C:16]7[CH:15]=[CH:14][C:13]([O:12][CH3:11])=[CH:18][CH:17]=7)[CH2:20][C@H:21]6[C:22](=[O:82])[N:23]([CH2:74][O:75][CH2:76][CH2:77][Si:78]([CH3:79])([CH3:81])[CH3:80])[C:24]=5[CH:33]=4)=[CH:40][C:41]=2[N:47]([CH2:48][O:49][CH2:50][CH2:51][Si:52]([CH3:53])([CH3:54])[CH3:55])[C:46]3=[O:56])[CH:5]=[CH:6][CH:7]=1