(3-(1,3-Thiazol-4-yl)phenyl)methanol → 1083300-27-9
反応式
[S:1]1[CH:5]=[C:4]([C:6]2[CH:7]=[C:8]([CH2:12][OH:13])[CH:9]=[CH:10][CH:11]=2)[N:3]=[CH:2]1>C(Cl)Cl.O=[Mn]=O>[S:1]1[CH:5]=[C:4]([C:6]2[CH:7]=[C:8]([CH:9]=[CH:10][CH:11]=2)[CH:12]=[O:13])[N:3]=[CH:2]1参加物
4
実験手順
A solution of (3-(thiazol-4-yl)phenyl)methanol (333 mg; 1.74 mmol) in anh. DCM (17 ml) was treated with MnO2 (2.276 g; 26.18 mmol), and the resulting mixture was stirred at rt, under nitrogen, for 1 h 45. The resulting reaction mixture was then filtered over celite, and the separated solids were washed with DCM. The filtrate was concentrated to dryness under reduced pressure giving 3-(thiazol-4-yl)benzaldehyde as a pale yellow solid. LC-MS (conditions A): tR=0.62 min.; [M+H]+: 190.13 g/mol.
後処理
- customThe resulting reaction mixture
- filtrationwas then filtered over celite
- washthe separated solids were washed with DCM
- concentrationThe filtrate was concentrated to dryness under reduced pressure
出典と根拠
- ORDレコード
- ord-6d38a0f7347f4f529eefdd70ede9ae4c
- 出典データセット
- uspto-grants-2016_01
- 特許番号
- US09242970B2
反応ノート
読み込み中…