HCID 69082439、化合物 → HCID 86695612、化合物
反応式
[S:1]1[C:5]([C:6]2[CH:7]=[C:8]([CH2:12][OH:13])[CH:9]=[CH:10][CH:11]=2)=[CH:4][N:3]=[CH:2]1>C(Cl)Cl.O=[Mn]=O>[S:1]1[C:5]([C:6]2[CH:7]=[C:8]([CH:9]=[CH:10][CH:11]=2)[CH:12]=[O:13])=[CH:4][N:3]=[CH:2]1参加物
4
実験手順
A solution of (3-(thiazol-5-yl)phenyl)methanol (162 mg; 0.84 mmol) in anh. DCM (6 ml) was treated with MnO2 (1.104 g; 12.70 mmol), and the resulting mixture was stirred at rt, under nitrogen, for 3 h. The resulting reaction mixture was then filtered over celite, and the separated solids were washed with DCM. The filtrate was concentrated to dryness under reduced pressure giving 3-(thiazol-5-yl)benzaldehyde as an orange solid. LC-MS (conditions A): tR=0.58 min.; [M+H]+: 190.02 g/mol.
後処理
- customThe resulting reaction mixture
- filtrationwas then filtered over celite
- washthe separated solids were washed with DCM
- concentrationThe filtrate was concentrated to dryness under reduced pressure
出典と根拠
- ORDレコード
- ord-c7018134b0b64f61b0ea05b4db520123
- 出典データセット
- uspto-grants-2016_01
- 特許番号
- US09242970B2
反応ノート
読み込み中…