(3-(5-Methylthiazol-2-yl)phenyl)methanol → 3-(5-Methylthiazol-2-yl)benzaldehyde
反応式
[CH3:1][C:2]1[S:6][C:5]([C:7]2[CH:8]=[C:9]([CH2:13][OH:14])[CH:10]=[CH:11][CH:12]=2)=[N:4][CH:3]=1>C(Cl)Cl.O=[Mn]=O>[CH3:1][C:2]1[S:6][C:5]([C:7]2[CH:8]=[C:9]([CH:10]=[CH:11][CH:12]=2)[CH:13]=[O:14])=[N:4][CH:3]=1参加物
4
実験手順
A solution of (3-(5-methylthiazol-2-yl)phenyl)methanol (210 mg; 1.02 mmol) in anh. DCM (8 ml) was treated with MnO2 (1.334 g; 15.34 mmol), and the resulting mixture was stirred at rt, under nitrogen, for 1.5 h. The resulting reaction mixture was then filtered over celite, and the separated solids were washed with DCM. The filtrate was concentrated to dryness under reduced pressure giving 3-(5-methylthiazol-2-yl)benzaldehyde as a colorless solid. LC-MS (conditions A): tR=0.72 min.; [M+H]+: 203.99 g/mol.
後処理
- customThe resulting reaction mixture
- filtrationwas then filtered over celite
- washthe separated solids were washed with DCM
- concentrationThe filtrate was concentrated to dryness under reduced pressure
出典と根拠
- ORDレコード
- ord-fe539833c462414f83844ae0aa2e46db
- 出典データセット
- uspto-grants-2016_01
- 特許番号
- US09242970B2
反応ノート
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