(3-(2H-1,2,3-triazol-2-yl)phenyl)methanol → 3-(2H-1,2,3-triazol-2-yl)benzaldehyde

HRID 594249ノート

反応式

HRID 594249 の反応式
[N:1]1[N:2]([C:6]2[CH:7]=[C:8]([CH2:12][OH:13])[CH:9]=[CH:10][CH:11]=2)[N:3]=[CH:4][CH:5]=1>C(Cl)Cl.O=[Mn]=O>[N:1]1[N:2]([C:6]2[CH:7]=[C:8]([CH:9]=[CH:10][CH:11]=2)[CH:12]=[O:13])[N:3]=[CH:4][CH:5]=1

参加物

4

反応物 1

HCID 53488009(3-(2H-1,2,3-triazol-2-yl)phenyl)methanol

生成物 1

HCID 834815283-(2H-1,2,3-triazol-2-yl)benzaldehyde

試薬・触媒・溶媒 2

HCID 14801Manganese dioxide触媒HCID 6344Dichloromethane溶媒

実験手順

A solution of (3-(2H-1,2,3-triazol-2-yl)phenyl)methanol (425 mg; 2.42 mmol) in anh. DCM (24 ml) was treated with MnO2 (3.165 g; 36.41 mmol), and the resulting mixture was stirred at rt, under nitrogen, for 1.5 h. The resulting reaction mixture was then filtered over celite, and the separated solids were washed with DCM. The filtrate was concentrated to dryness under reduced pressure giving 3-(2H-1,2,3-triazol-2-yl)benzaldehyde as a pale yellow solid. LC-MS (conditions A): tR=0.63 min.; no ionisation.

後処理

  1. customThe resulting reaction mixture
  2. filtrationwas then filtered over celite
  3. washthe separated solids were washed with DCM
  4. concentrationThe filtrate was concentrated to dryness under reduced pressure

出典と根拠

ORDレコード
ord-198db9f03f2b4a04a5a8423a71ed396e
出典データセット
uspto-grants-2016_01
特許番号
US09242970B2

反応ノート

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