(2-(1H-Pyrazol-1-YL)pyridin-4-YL)methanol → 2-(1H-pyrazol-1-yl)isonicotinaldehyde

HRID 594255ノート

反応式

HRID 594255 の反応式
[N:1]1([C:6]2[CH:11]=[C:10]([CH2:12][OH:13])[CH:9]=[CH:8][N:7]=2)[CH:5]=[CH:4][CH:3]=[N:2]1>ClCCCl.O=[Mn]=O>[N:1]1([C:6]2[CH:11]=[C:10]([CH:9]=[CH:8][N:7]=2)[CH:12]=[O:13])[CH:5]=[CH:4][CH:3]=[N:2]1

参加物

4

反応物 1

HCID 61256684(2-(1H-Pyrazol-1-YL)pyridin-4-YL)methanol

生成物 1

HCID 866956132-(1H-pyrazol-1-yl)isonicotinaldehyde

試薬・触媒・溶媒 2

HCID 14801Manganese dioxide触媒HCID 111,2-Dichloroethane溶媒

実験手順

A solution of (2-(1H-pyrazol-1-yl)pyridin-4-yl)methanol (217 mg; 1.23 mmol) in anh. DCE (4 ml) was treated with MnO2 (861 mg; 9.91 mmol), and the resulting mixture was stirred at reflux, under nitrogen, for 1.5 h. After cooling to rt, the resulting reaction mixture was filtered over celite, and the separated solids were washed with DCM. The filtrate was concentrated to dryness under reduced pressure giving 2-(1H-pyrazol-1-yl)isonicotinaldehyde as a colorless solid. LC-MS (conditions C): tR=0.70 min.; [M+H]+: 173.76 g/mol.

後処理

  1. temperatureat reflux, under nitrogen, for 1.5 h
  2. customthe resulting reaction mixture
  3. filtrationwas filtered over celite
  4. washthe separated solids were washed with DCM
  5. concentrationThe filtrate was concentrated to dryness under reduced pressure

出典と根拠

ORDレコード
ord-cc8bd2ae05df457fad3193ded08c17cb
出典データセット
uspto-grants-2016_01
特許番号
US09242970B2

反応ノート

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