(2-(4-Methylthiazol-2-yl)pyridin-4-yl)methanol → 2-(4-Methylthiazol-2-yl)isonicotinaldehyde
反応式
[CH3:1][C:2]1[N:3]=[C:4]([C:7]2[CH:12]=[C:11]([CH2:13][OH:14])[CH:10]=[CH:9][N:8]=2)[S:5][CH:6]=1>ClCCCl.O=[Mn]=O>[CH3:1][C:2]1[N:3]=[C:4]([C:7]2[CH:12]=[C:11]([CH:10]=[CH:9][N:8]=2)[CH:13]=[O:14])[S:5][CH:6]=1参加物
4
実験手順
A solution of (2-(4-methylthiazol-2-yl)pyridin-4-yl)methanol (750 mg; 3.64 mmol) in anh. DCE (40 ml) was treated with MnO2 (1.581 g; 18.20 mmol), and the resulting mixture was heated at reflux, under nitrogen, for 1.5 h. After cooling to rt, the resulting reaction mixture was filtered over celite, and the separated solids were washed with DCM. The filtrate was concentrated to dryness under reduced pressure giving 2-(4-methylthiazol-2-yl)isonicotinaldehyde as an off-white solid. LC-MS (conditions A): tR=0.64 min.; [M+H]+: 205.04 g/mol.
後処理
- temperaturethe resulting mixture was heated
- temperatureat reflux, under nitrogen, for 1.5 h
- customthe resulting reaction mixture
- filtrationwas filtered over celite
- washthe separated solids were washed with DCM
- concentrationThe filtrate was concentrated to dryness under reduced pressure
出典と根拠
- ORDレコード
- ord-984b2cad35f944ea8766820f9c0eb8f0
- 出典データセット
- uspto-grants-2016_01
- 特許番号
- US09242970B2
反応ノート
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