(2-(5-Methylthiazol-2-yl)pyridin-4-yl)methanol → 2-(5-Methylthiazol-2-yl)isonicotinaldehyde

HRID 594296ノート

反応式

HRID 594296 の反応式
[CH3:1][C:2]1[S:6][C:5]([C:7]2[CH:12]=[C:11]([CH2:13][OH:14])[CH:10]=[CH:9][N:8]=2)=[N:4][CH:3]=1>ClCCCl.O=[Mn]=O>[CH3:1][C:2]1[S:6][C:5]([C:7]2[CH:12]=[C:11]([CH:10]=[CH:9][N:8]=2)[CH:13]=[O:14])=[N:4][CH:3]=1

参加物

4

反応物 1

HCID 69084104(2-(5-Methylthiazol-2-yl)pyridin-4-yl)methanol

生成物 1

HCID 866956202-(5-Methylthiazol-2-yl)isonicotinaldehyde

試薬・触媒・溶媒 2

HCID 14801Manganese dioxide触媒HCID 111,2-Dichloroethane溶媒

実験手順

A solution of (2-(5-methylthiazol-2-yl)pyridin-4-yl)methanol (1.910 g; 9.26 mmol) in anh. DCE (80 ml) was treated with MnO2 (4.025 g; 46.30 mmol), and the resulting mixture was heated at reflux, under nitrogen, for 1.5 h. After cooling to rt, the resulting reaction mixture was filtered over celite, and the separated solids were washed with DCM. The filtrate was concentrated to dryness under reduced pressure giving 2-(5-methylthiazol-2-yl)isonicotinaldehyde as an off-white solid. LC-MS (conditions A): tR=0.65 min.; [M+H]+: 205.35 g/mol.

後処理

  1. temperaturethe resulting mixture was heated
  2. temperatureat reflux, under nitrogen, for 1.5 h
  3. customthe resulting reaction mixture
  4. filtrationwas filtered over celite
  5. washthe separated solids were washed with DCM
  6. concentrationThe filtrate was concentrated to dryness under reduced pressure

出典と根拠

ORDレコード
ord-b54819fc474c4e8cace0e9fd001506fd
出典データセット
uspto-grants-2016_01
特許番号
US09242970B2

反応ノート

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