Hydrochloric Acid → (6-methoxynaphthalen-2-yl)methanol

HRID 594321ノート

反応式

HRID 594321 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[CH:9]=[C:8]([CH:13]=[O:14])[CH:7]=[CH:6]2.[BH4-].[Na+].Cl>CO>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[CH:9]=[C:8]([CH2:13][OH:14])[CH:7]=[CH:6]2

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 769916-Methoxy-2-naphthaldehydeHCID 4311764Sodium borohydride

生成物 1

HCID 10012701(6-methoxynaphthalen-2-yl)methanol

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A solution of commercially available 6-methoxy-2-naphthaldehyde (200 mg; 1.07 mmol) in MeOH (5 ml) was treated portionwise at rt with NaBH4 (50 mg; 1.31 mmol), and the resulting mixture was further stirred at rt, under nitrogen, for 1 h. 2 M aq. HCl was added, and the organic solvent was removed under reduced pressure. AcOEt and water were added, and the separated organic layer was dried over anh. MgSO4, filtered, and concentrated to dryness under reduced pressure affording (6-methoxynaphthalen-2-yl)methanol as a colorless solid. LC-MS (conditions E): tR=0.55 min.; no ionisation.

後処理

  1. customthe organic solvent was removed under reduced pressure
  2. additionAcOEt and water were added
  3. dry with materialthe separated organic layer was dried over anh. MgSO4
  4. filtrationfiltered
  5. concentrationconcentrated to dryness under reduced pressure

出典と根拠

ORDレコード
ord-1be3265d43d042ee96a7d9f08bf7dd1a
出典データセット
uspto-grants-2016_01
特許番号
US09242970B2

反応ノート

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