Methanol → 5-fluoro-3-methyl-1H-indole-2-propanoic acid

HRID 5944ノート

反応式

HRID 5944 の反応式
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6]([CH2:11][CH2:12][C:13]([O:15]C(C)C)=[O:14])=[C:5]2[CH3:19].[OH-].[Na+].CO>O>[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6]([CH2:11][CH2:12][C:13]([OH:15])=[O:14])=[C:5]2[CH3:19]

参加物

5

反応物 3

HCID 887MethanolHCID 14798Sodium HydroxideHCID 19794669isopropyl 5-fluoro-3-methyl-1H-indole-2-propanoate

生成物 1

HCID 221411665-fluoro-3-methyl-1H-indole-2-propanoic acid収率 102%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture of isopropyl 5-fluoro-3-methyl-1H-indole-2-propanoate (0.42 g),1N sodiumhydroxide (6.3 ml) and methanol (20 ml) are stirred at room temperature for 4 hours. The reaction mixture is poured into water, washed with methylene chloride, acidified with 1N HCl and extracted with methylene chloride. The organic layer, dried and evaporated, affords 0.36 g of 5-fluoro-3-methyl-1H-indole-2-propanoic acid.

後処理

  1. washwashed with methylene chloride
  2. extractionextracted with methylene chloride
  3. customThe organic layer, dried
  4. customevaporated

出典と根拠

ORDレコード
ord-ce2094f8a0e9499fa6e6eca4f823126b
出典データセット
uspto-grants-1993_09
特許番号
US05246957

反応ノート

読み込み中…