4-Trifluoromethyl-1,2-phenylenediamine → HCID 178493038、化合物

HRID 59479

反応式

HRID 59479 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[C:9]1[NH:13][C:12](=[O:14])[N:11]([C:15]2[CH:24]=[CH:23][C:18]([C:19](OC)=O)=[C:17]([O:25][CH3:26])[CH:16]=2)[N:10]=1.[F:27][C:28]([F:38])([F:37])[C:29]1[CH:30]=[C:31]([NH2:36])[C:32]([NH2:35])=[CH:33][CH:34]=1.C[Al](C)C>C1(C)C=CC=CC=1>[Cl:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[C:3]=1[C:9]1[NH:13][C:12](=[O:14])[N:11]([C:15]2[CH:24]=[CH:23][C:18]([C:19]3[NH:35][C:32]4[CH:33]=[CH:34][C:29]([C:28]([F:27])([F:37])[F:38])=[CH:30][C:31]=4[N:36]=3)=[C:17]([O:25][CH3:26])[CH:16]=2)[N:10]=1

参加物

5

反応物 3

HCID 5208224-Trifluoromethyl-1,2-phenylenediamineHCID 16682925TrimethylaluminumHCID 136492365methyl 4-(3-(2,6-dichlorophenyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)-2-methoxybenzoate

生成物 1

HCID 178493038HCID 178493038、化合物収率 9.6%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

The title compound was prepared by following the procedure as described for Example-31 by using methyl 4-(3-(2,6-dichlorophenyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)-2-methoxybenzoate (Intermediate-21, 0.150 g, 0.30 mmol), 4-(trifluoromethyl)benzene-1,2-diamine (0.081 g, 0.45 mmol), trimethyl aluminium (2M solution in toluene) (2 mL), dry toluene (5.0 mL) to afford 0.015 g of desired product. 1H NMR (300 MHz, DMSO d6): δ 4.09 (s, 3H), 7.52 (s, 1H), 7.73-7.85 (m, 5H), 8.02-8.15 (m, 2H), 8.48 (m, 1H), 12.79 (br s, 1H), 13.33 (br s, 1H); MS (m/z): 520.14 (M+H)+.

後処理

  1. customThe title compound was prepared

出典と根拠

ORDレコード
ord-0f3874073aa64b0591d7f7fa0d5b6057
出典データセット
uspto-grants-2016_09
特許番号
US09439890B2

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