Methyl iodide → HCID 56980471、化合物
反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][S:9]([CH3:12])(=[O:11])=[O:10])=[CH:4][CH:3]=1.[C:13](=O)([O-])[O-].[K+].[K+].CI>CN(C=O)C.CCOC(C)=O>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]([CH3:13])[S:9]([CH3:12])(=[O:11])=[O:10])=[CH:6][CH:7]=1参加物
6
実験手順
A solution of N-(4-bromophenyl)methanesulfonamide (200 mg, 0.80 mmol), potassium carbonate (2 eq) and methyl iodide (2 eq) in DMF (2 mL) was heated at 60° C. for 18 h. After cooling to rt the mixture was diluted with EtOAc and washed with water. The organic phase was collected, dried (MgSO4) and concentrated in vacuo to give N-(4-bromophenyl)-N-methylmethanesulfonamide.
後処理
- washwashed with water
- customThe organic phase was collected
- dry with materialdried (MgSO4)
- concentrationconcentrated in vacuo
出典と根拠
- ORDレコード
- ord-5c7e8df5d9c2428a852c19dd1f93bb63
- 出典データセット
- uspto-grants-2016_01
- 特許番号
- US09242987B2
反応ノート
読み込み中…