Lithium borohydride → (2-Fluoro-3-morpholinophenyl)methanol
反応式
[F:1][C:2]1[C:16]([N:17]2[CH2:22][CH2:21][O:20][CH2:19][CH2:18]2)=[CH:15][CH:14]=[CH:13][C:3]=1[C:4](OCCOCCBr)=[O:5].[BH4-].[Li+]>C1COCC1>[F:1][C:2]1[C:16]([N:17]2[CH2:22][CH2:21][O:20][CH2:19][CH2:18]2)=[CH:15][CH:14]=[CH:13][C:3]=1[CH2:4][OH:5]参加物
4
実験手順
To a solution of 2-(2-bromoethoxy)ethyl 2-fluoro-3-morpholinobenzoate (450 mg, 1.2 mmol) in THF (5 mL) was added lithium borohydride (1.5 eq) and the reaction stirred at rt for 18 h. The reaction was quenched by addition of saturated NH4Cl (aq) and extracted with EtOAc. The organic phase was dried (Na2SO4), filtered and concentrated in vacuo. The resultant residue was purified by column chromatography (petroleum ether: EtOAc) to give (2-fluoro-3-morpholinophenyl)methanol.
後処理
- customThe reaction was quenched by addition of saturated NH4Cl (aq)
- extractionextracted with EtOAc
- dry with materialThe organic phase was dried (Na2SO4)
- filtrationfiltered
- concentrationconcentrated in vacuo
- customThe resultant residue was purified by column chromatography (petroleum ether: EtOAc)
出典と根拠
- ORDレコード
- ord-f87401f5016a497a8fe2101d9a14c525
- 出典データセット
- uspto-grants-2016_01
- 特許番号
- US09242987B2
反応ノート
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