関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Diethyl Oxalate | HCID 7268 | — |
| 反応物 | Hexane | HCID 8058 | — |
| 反応物 | 1-(5-Methylpyridin-3-yl)ethan-1-one | HCID 577569 | — |
| 反応物 | Sodium ethoxide | HCID 2723922 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | HCID 178473093 | HCID 178473093 | — |
反応手順
To a mixture of 1-2 (0.5 g, 3.70 mmol) and diethyl oxalate (1.010 ml, 7.40 mmol) in THF (15 ml) was added sodium ethoxide (3.45 ml, 21% wt. in ethanol, 9.25 mmol). The resulting mixture was heated at 60° C. for 1 h followed by stirring at rt overnight. The reaction mixture was poured into cold hexane and the desire product 1-3 was collected as a light yellow solid: ESI+ MS [M+H]+ C12H14NO4=236.1.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US09242995B2 |
|---|
| 出典データセット | uspto-grants-2016_01 |
|---|
| ORD ID | ord-0112dac7227f4bdc8ff4d33fb0395708 |
|---|
| 出典メモ | uspto-grants-2016_01 |
|---|
