1,2-Dichloroethane → (5-Chlorocarbonyl-pyridin-2-yl)-ethyl-carbamic acid tert-butyl ester

HRID 595088

反応式

HRID 595088 の反応式
[C:1]([O:5][C:6]([N:8]([CH2:18][CH3:19])[C:9]1[CH:17]=[CH:16][C:12]([C:13](O)=[O:14])=[CH:11][N:10]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[Cl:20]CCCl>>[C:1]([O:5][C:6](=[O:7])[N:8]([C:9]1[CH:17]=[CH:16][C:12]([C:13]([Cl:20])=[O:14])=[CH:11][N:10]=1)[CH2:18][CH3:19])([CH3:4])([CH3:3])[CH3:2]

参加物

3

反応物 2

HCID 111,2-DichloroethaneHCID 667695526-(((Tert-butoxy)carbonyl)(ethyl)amino)pyridine-3-carboxylic acid

生成物 1

HCID 86664610(5-Chlorocarbonyl-pyridin-2-yl)-ethyl-carbamic acid tert-butyl ester

実験手順

6-(tert-Butoxycarbonyl-ethyl-amino)-nicotinic acid (6.40 g, 24.0 mmol) is taken up in 150 mL DCE, 1-chloro-N,N-2-trimethylpropenyl-amine (6.42 mL, 48.1 mmol) is added and the reaction mixture is stirred overnight at RT. The reaction mixture is concentrated under reduced pressure and the crude product is used in the next step without purification.

後処理

  1. concentrationThe reaction mixture is concentrated under reduced pressure
  2. customthe crude product is used in the next step without purification

出典と根拠

ORDレコード
ord-068c5445f3374fb9b532cbba1e893995
出典データセット
uspto-grants-2016_01
特許番号
US09243000B2

関連ノート

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