5-(3,6-dihydro-2H-thiopyran-4-yl)pyridin-2-amine → 5-(tetrahydro-2H-thiopyran-4-yl)pyridin-2-amine
反応式
[S:1]1[CH2:6][CH:5]=[C:4]([C:7]2[CH:8]=[CH:9][C:10]([NH2:13])=[N:11][CH:12]=2)[CH2:3][CH2:2]1>CO.C(Cl)Cl.[Pd]>[S:1]1[CH2:2][CH2:3][CH:4]([C:7]2[CH:8]=[CH:9][C:10]([NH2:13])=[N:11][CH:12]=2)[CH2:5][CH2:6]1参加物
5
実験手順
A suspension of 5-(3,6-dihydro-2H-thiopyran-4-yl)pyridin-2-amine (260 mg, 1.35 mmol), Pd/C (36 mg, 0.33 mmol) in methanol (16 mL) was stirred under hydrogen at ambient temperature for 16 h. The reaction mixture was diluted with DCM (80 mL), and was filtered through Celite. The filtrate was concentrated to give 5-(tetrahydro-2H-thiopyran-4-yl)pyridin-2-amine (240 mg, 91% yield) as yellow color solid. LCMS (m/z): 195 (MH+), 0.46 min.
後処理
- filtrationwas filtered through Celite
- concentrationThe filtrate was concentrated
出典と根拠
- ORDレコード
- ord-4a23599ccaad4baab79178c67865d0b2
- 出典データセット
- uspto-grants-2016_01
- 特許番号
- US09242996B2
反応ノート
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