Trifluoroacetic acid → 3-Bromo-5-(pyrrolidin-3-yl)pyridin-2-amine

HRID 595818ノート

反応式

HRID 595818 の反応式
[NH2:1][C:2]1[N:7]=[CH:6][C:5]([CH:8]2[CH2:12][CH2:11][N:10](C(OC(C)(C)C)=O)[CH2:9]2)=[CH:4][C:3]=1[Br:20].C(O)(C(F)(F)F)=O>C(Cl)Cl>[Br:20][C:3]1[C:2]([NH2:1])=[N:7][CH:6]=[C:5]([CH:8]2[CH2:12][CH2:11][NH:10][CH2:9]2)[CH:4]=1

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 118045605Tert-butyl 3-(6-amino-5-bromopyridin-3-yl)pyrrolidine-1-carboxylate

生成物 1

HCID 1180452883-Bromo-5-(pyrrolidin-3-yl)pyridin-2-amine

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To tert-butyl 3-(6-amino-5-bromopyridin-3-yl)pyrrolidine-1-carboxylate (65 mg, 0.171 mmol) in DCM (2.4 mL) was added TFA (0.6 mL, 7.79 mmol). The reaction mixture was stirred at room temperature for 45 min. The reaction mixture was evaporated in vacuo after dilution with toluene. The crude product was used for next step without purification. The crude yield was quantitative. LCMS (m/z): 242.1/244.1 (MH+), 0.214 min.

後処理

  1. customThe reaction mixture was evaporated in vacuo after dilution with toluene
  2. customThe crude product was used for next step without purification
  3. customThe crude yield
  4. custom242.1/244.1 (MH+), 0.214 min.

出典と根拠

ORDレコード
ord-04113b0eb5ad4b289d34ce7c7f3e1272
出典データセット
uspto-grants-2016_01
特許番号
US09242996B2

反応ノート

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