Trifluoroacetic acid → 4-(6-fluoropyridin-3-yl)-1H-pyrrol-2(5H)-one
反応式
[F:1][C:2]1[N:7]=[CH:6][C:5]([C:8]2[CH2:12][N:11](C(OC(C)(C)C)=O)[C:10](=[O:20])[CH:9]=2)=[CH:4][CH:3]=1.C(O)(C(F)(F)F)=O>C(Cl)Cl>[F:1][C:2]1[N:7]=[CH:6][C:5]([C:8]2[CH2:12][NH:11][C:10](=[O:20])[CH:9]=2)=[CH:4][CH:3]=1参加物
4
実験手順
To tert-butyl 4-(6-fluoropyridin-3-yl)-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxylate (315 mg, 1.132 mmol) in DCM (4 mL) was added TFA (1 mL, 12.98 mmol). The reaction mixture was stirred at room temperature for 1 h. Reaction mixture was evaporated. Azeotrope with toluene (x=3) yielding 4-(6-fluoropyridin-3-yl)-1H-pyrrol-2(5H)-one. Proceed for next step. LCMS (m/z): 179.2 (MH+), 0.373 min. The crude yield was quantitative.
後処理
- customReaction mixture
- customwas evaporated
出典と根拠
- ORDレコード
- ord-76423177b78842f4a17e4e42eecbd4dc
- 出典データセット
- uspto-grants-2016_01
- 特許番号
- US09242996B2
反応ノート
読み込み中…