4-(6-fluoropyridin-3-yl)-1H-pyrrol-2(5H)-one → 4-(6-Fluoropyridin-3-yl)pyrrolidin-2-one
反応式
[F:1][C:2]1[N:7]=[CH:6][C:5]([C:8]2[CH2:12][NH:11][C:10](=[O:13])[CH:9]=2)=[CH:4][CH:3]=1>CO.[Pd]>[F:1][C:2]1[N:7]=[CH:6][C:5]([CH:8]2[CH2:12][NH:11][C:10](=[O:13])[CH2:9]2)=[CH:4][CH:3]=1参加物
4
実験手順
To 4-(6-fluoropyridin-3-yl)-1H-pyrrol-2(5H)-one(190 mg, 1.066 mmol) in MeOH (10 mL) under N2 atmosphere was added Pd—C (227 mg, 0.213 mmol). The reaction mixture was stirred under H2 balloon at room temperature for overnight. Reaction mixture was filtered through Celite, washed with MeOH. Filtrate was evaporated. Azeotrope with toluene (x=3). Yield was 80%. Proceed for next step. LCMS (m/z): 181.0 (MH+), 0.341 min.
後処理
- customReaction mixture
- filtrationwas filtered through Celite
- washwashed with MeOH
- customFiltrate was evaporated
- custom181.0 (MH+), 0.341 min.
出典と根拠
- ORDレコード
- ord-9229717d83af421c9cbec786ffe28491
- 出典データセット
- uspto-grants-2016_01
- 特許番号
- US09242996B2
反応ノート
読み込み中…