Diisopropylethylamine → (S)-tert-butyl (4-(5-amino-6-(4-((1-(3-chlorophenyl)-2-hydroxyethyl)carbamoyl)-3-fluorophenyl)pyrazin-2-yl)cyclohexyl)carbamate

反応式

[NH2:1][C:2]1[C:3]([C:22]2[CH:30]=[CH:29][C:25]([C:26]([OH:28])=O)=[C:24]([F:31])[CH:23]=2)=[N:4][C:5]([CH:8]2[CH2:13][CH2:12][CH:11]([NH:14][C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])[CH2:10][CH2:9]2)=[CH:6][N:7]=1.CCN(C(C)C)C(C)C.[NH2:41][C@@H:42]([C:45]1[CH:50]=[CH:49][CH:48]=[C:47]([Cl:51])[CH:46]=1)[CH2:43][OH:44].CN(C(ON1N=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F>C(OCC)(=O)C.CS(C)=O>[NH2:1][C:2]1[N:7]=[CH:6][C:5]([CH:8]2[CH2:13][CH2:12][CH:11]([NH:14][C:15](=[O:16])[O:17][C:18]([CH3:21])([CH3:19])[CH3:20])[CH2:10][CH2:9]2)=[N:4][C:3]=1[C:22]1[CH:30]=[CH:29][C:25]([C:26](=[O:28])[NH:41][C@@H:42]([C:45]2[CH:50]=[CH:49][CH:48]=[C:47]([Cl:51])[CH:46]=2)[CH2:43][OH:44])=[C:24]([F:31])[CH:23]=1