Propylenediamine → 1-Methyl-2-(3-phenylureido)ethylamine
反応式
[C:1]1([NH:7][C:8](=[O:12])OCC)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH2:13][CH2:14][CH:15]([NH2:17])[CH3:16]>>[CH3:16][CH:15]([NH2:17])[CH2:14][NH:13][C:8]([NH:7][C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1)=[O:12]参加物
3
反応条件
- 温度
- 125 °C
実験手順
A mixture of ethyl phenylcarbamate (50 g.) and 1,2-diaminopropane (105 g.) is heated at 125° C. for 17 hours and cooled, and the excess of amine is removed by evaporation under reduced pressure. The residue is dissolved in ethyl acetate and the solution is washed with saturated brine, dried and evaporated to dryness. The residue is triturated with toluene and there is thus obtained as solid residue 1-methyl-2-(3-phenylureido)ethylamine, which is used without further purification.
後処理
- temperaturecooled
- customthe excess of amine is removed by evaporation under reduced pressure
- dissolutionThe residue is dissolved in ethyl acetate
- washthe solution is washed with saturated brine
- customdried
- customevaporated to dryness
- customThe residue is triturated with toluene and there
出典と根拠
- ORDレコード
- ord-7c1c6a51820c41698586f9e35be17bd5
- 出典データセット
- uspto-grants-1977_03
- 特許番号
- US04010189
反応ノート
読み込み中…