Propylenediamine → 1-Methyl-2-(3-phenylureido)ethylamine

HRID 596236

反応式

HRID 596236 の反応式
[C:1]1([NH:7][C:8](=[O:12])OCC)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH2:13][CH2:14][CH:15]([NH2:17])[CH3:16]>>[CH3:16][CH:15]([NH2:17])[CH2:14][NH:13][C:8]([NH:7][C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1)=[O:12]

参加物

3

反応物 2

HCID 6567PropylenediamineHCID 7591Ethyl N-phenylcarbamate

生成物 1

HCID 536666351-Methyl-2-(3-phenylureido)ethylamine

反応条件

温度
125 °C

実験手順

A mixture of ethyl phenylcarbamate (50 g.) and 1,2-diaminopropane (105 g.) is heated at 125° C. for 17 hours and cooled, and the excess of amine is removed by evaporation under reduced pressure. The residue is dissolved in ethyl acetate and the solution is washed with saturated brine, dried and evaporated to dryness. The residue is triturated with toluene and there is thus obtained as solid residue 1-methyl-2-(3-phenylureido)ethylamine, which is used without further purification.

後処理

  1. temperaturecooled
  2. customthe excess of amine is removed by evaporation under reduced pressure
  3. dissolutionThe residue is dissolved in ethyl acetate
  4. washthe solution is washed with saturated brine
  5. customdried
  6. customevaporated to dryness
  7. customThe residue is triturated with toluene and there

出典と根拠

ORDレコード
ord-7c1c6a51820c41698586f9e35be17bd5
出典データセット
uspto-grants-1977_03
特許番号
US04010189

関連ノート

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