Tetrahydrofuran → HCID 21433688、化合物

反応式

[C:1]([C:3]1([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH2:8][CH2:7][CH:6]([OH:9])[CH2:5][CH2:4]1)#N.[H-].[Al+3].[Li+].[H-].[H-].[H-].[O:22]1CCCC1>>[OH:9][CH:6]1[CH2:7][CH2:8][C:3]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)([CH:1]=[O:22])[CH2:4][CH2:5]1

参加物

反応物 3

HCID 8028Tetrahydrofuran

HCID 124536734-Hydroxy-1-phenylcyclohexane-1-carbonitrile

HCID 21226445Aluminium lithium hydride

生成物 1

HCID 21433688HCID 21433688、化合物

実験手順

A thus produced 4-cyano-4-phenylcyclohexanol (b) obtained in step (1) is directly reduced, e.g., with lithium aluminum hydride (in a solvent such as tetrahydrofuran) at elevated (reflux) temperature, to give a corresponding 4-hydroxy-1-phenyl-1-cyclohexanecarboxaldehyde (c). This compound is also prepared via the tetrahydropyranyl ether of (b).

出典と根拠

ORDレコード: ord-53f041787cfe46bbbad94aafc981ad64
出典データセット: uspto-grants-1977_03
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04010201

反応ノート

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