2-(Pyridin-2-yloxy)ethanamine → N-[2-(2-Pyridyloxy)ethyl]3-Carbethoxymethyl-7,8-dimethoxypyrimido[4,5-b]quinolin-4(3H)-one-2-carboxamide

HRID 596598ノート

反応式

HRID 596598 の反応式
[C:1]([CH2:6][N:7]1[C:20](=[O:21])[C:19]2[C:10](=[N:11][C:12]3[C:17]([CH:18]=2)=[CH:16][C:15]([O:22][CH3:23])=[C:14]([O:24][CH3:25])[CH:13]=3)[N:9]=[C:8]1[C:26](OCC)=[O:27])([O:3][CH2:4][CH3:5])=[O:2].[N:31]1[CH:36]=[CH:35][CH:34]=[CH:33][C:32]=1[O:37][CH2:38][CH2:39][NH2:40]>C(Cl)(Cl)Cl>[N:31]1[CH:36]=[CH:35][CH:34]=[CH:33][C:32]=1[O:37][CH2:38][CH2:39][NH:40][C:26]([C:8]1[N:7]([CH2:6][C:1]([O:3][CH2:4][CH3:5])=[O:2])[C:20](=[O:21])[C:19]2[C:10]([N:9]=1)=[N:11][C:12]1[C:17]([CH:18]=2)=[CH:16][C:15]([O:22][CH3:23])=[C:14]([O:24][CH3:25])[CH:13]=1)=[O:27]

参加物

4

反応物 2

HCID 968902-(Pyridin-2-yloxy)ethanamineHCID 22752836ethyl 3-carbethoxymethyl-7,8-dimethoxypyrimido[4,5-b]quinolin-4(3H)-one-2-carboxylate

生成物 1

HCID 21450316N-[2-(2-Pyridyloxy)ethyl]3-Carbethoxymethyl-7,8-dimethoxypyrimido[4,5-b]quinolin-4(3H)-one-2-carboxamide

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

A solution of ethyl 3-carbethoxymethyl-7,8-dimethoxypyrimido[4,5-b]quinolin-4(3H)-one-2-carboxylate (0.415 g., 1mM) and 2-(2-pyridyloxy)ethylamine (0.276 g., 2 mM) in chloroform (10 ml.) is refluxed for 24 hours. It is then cooled to room temperature and concentrated in vacuo. The residue, an oil, is crystallized by addition of ether until precipitation is complete. Yield = 0.41 g. (81%) of product; m.p. 170°-180° C.

後処理

  1. concentrationconcentrated in vacuo
  2. customThe residue, an oil, is crystallized by addition of ether until precipitation

出典と根拠

ORDレコード
ord-5118ef0be7d04fc99186124e4a15065f
出典データセット
uspto-grants-1977_03
特許番号
US04011324

反応ノート

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