ホームMCPワークベンチSkills
ホームワークベンチ通知マイページ
llms.txt · MCPガイドプライバシーポリシー · 利用規約 · サポートv1.8.0
  1. ホーム
  2. /反応

m-Chloroperbenzoic acid → 4-(4-Cyano-2-methanesulfinyl-phenyl)-2,5-dioxo-1-(3-trifluoromethyl-phenyl)-1,4,5,6,7,8-hexahydro-2H-quinazoline-3-carboxylic acid methylamide

HRID 59660
ノート
印刷プレビュー

反応式

HRID 59660 の反応式
ClC1C=C(C=CC=1)C(OO)=[O:6].[CH3:12][NH:13][C:14]([N:16]1[CH:25]([C:26]2[CH:31]=[CH:30][C:29]([C:32]#[N:33])=[CH:28][C:27]=2[S:34][CH3:35])[C:24]2[C:23](=[O:36])[CH2:22][CH2:21][CH2:20][C:19]=2[N:18]([C:37]2[CH:42]=[CH:41][CH:40]=[C:39]([C:43]([F:46])([F:45])[F:44])[CH:38]=2)[C:17]1=[O:47])=[O:15]>ClCCl>[CH3:12][NH:13][C:14]([N:16]1[CH:25]([C:26]2[CH:31]=[CH:30][C:29]([C:32]#[N:33])=[CH:28][C:27]=2[S:34]([CH3:35])=[O:6])[C:24]2[C:23](=[O:36])[CH2:22][CH2:21][CH2:20][C:19]=2[N:18]([C:37]2[CH:42]=[CH:41][CH:40]=[C:39]([C:43]([F:45])([F:44])[F:46])[CH:38]=2)[C:17]1=[O:47])=[O:15]
参加物実験手順後処理出典と根拠反応ノート

参加物

4

反応物 2

HCID 70297m-Chloroperbenzoic acidHCID 1186928894-(4-Cyano-2-methylsulfanyl-phenyl)-2,5-dioxo-1-(3-trifluoromethyl-phenyl)-1,4,5,6,7,8-hexahydro-2H-quinazoline-3-carboxylic acid methylamide2 回

生成物 1

HCID 1186929114-(4-Cyano-2-methanesulfinyl-phenyl)-2,5-dioxo-1-(3-trifluoromethyl-phenyl)-1,4,5,6,7,8-hexahydro-2H-quinazoline-3-carboxylic acid methylamide

試薬・触媒・溶媒 1

HCID 6344Dichloromethane
溶媒

実験手順

3-Chloroperoxybenzoic acid (77%, 24 mg, 0.107 mmol) is added at room temperature to a solution of 4-(4-cyano-2-methylsulfanyl-phenyl)-2,5-dioxo-1-(3-trifluoromethyl-phenyl)-1,4,5,6,7,8-hexahydro-2H-quinazoline-3-carboxylic acid methylamide (INTERMEDIATE 8, 63 mg, 0.122 mmol) in dichloromethane (2 mL), and the mixture is stirred for 90 min. The reaction mixture is concentrated under reduced pressure and purified by reversed phase HPLC (X-Bridge C18, gradient of acetonitrile in water, 0.1% NH4OH) yielding the two diastereomers of the title compound.

後処理

  1. concentrationThe reaction mixture is concentrated under reduced pressure
  2. custompurified by reversed phase HPLC (X-Bridge C18, gradient of acetonitrile in water, 0.1% NH4OH)

出典と根拠

ORDレコード
ord-ae4936b8b9084b3aa1e4010ab3104b11
出典データセット
uspto-grants-2016_09
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US09440930B2

反応ノート

読み込み中…

このページの内容参加物実験手順後処理出典と根拠反応ノート