Styrene Oxide → HCID 10662045、化合物
反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:11][CH2:12][NH2:13])[CH:6]=[CH:7][C:8]=1[O:9][CH3:10].[CH2:14]1[O:22][CH:15]1[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>O1CCCC1>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:11][CH2:12][NH:13][CH2:14][CH:15]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[OH:22])[CH:6]=[CH:7][C:8]=1[O:9][CH3:10]参加物
4
実験手順
A mixture of 100 g. (0.55 mol) of 3,4-dimethoxyphenylethylamine and 66.2 g. (0.55 mol) of styrene oxide in 200 ml. of tetrahydrofuran is refluxed overnight. The solvent is removed in vacuo, about 500 ml. of n-butyl chloride is added and the mixture cooled slightly. Filtration furnishes N-[2-(3,4-dimethoxyphenyl)ethyl]-2-phenyl-2-hydroxyethylamine, m.p. 92°-93° C.
後処理
- additionA mixture of 100 g
- customThe solvent is removed in vacuo, about 500 ml
- additionof n-butyl chloride is added
- temperaturethe mixture cooled slightly
- filtrationFiltration
出典と根拠
- ORDレコード
- ord-b95514401995467184049839ff0bc30b
- 出典データセット
- uspto-grants-1977_03
- 特許番号
- US04011319
反応ノート
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