Benzoylacetone → Methanone, (3-methyl-1,4-dioxido-2-quinoxalinyl)phenyl-

HRID 596800

反応式

HRID 596800 の反応式
[N+:1]1([O-:10])[O:5][N:4]=[C:3]2[CH:6]=[CH:7][CH:8]=[CH:9][C:2]=12.[C:11]([CH2:19][C:20](=O)[CH3:21])(=[O:18])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.[OH-].[Na+]>C(O)C>[C:11]([C:19]1[C:20]([CH3:21])=[N+:4]([O-:5])[C:3]2[C:2](=[CH:9][CH:8]=[CH:7][CH:6]=2)[N+:1]=1[O-:10])(=[O:18])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

参加物

5

反応物 3

HCID 7166BenzoylacetoneHCID 14798Sodium HydroxideHCID 68075Benzofuroxan

生成物 1

HCID 178428812Methanone, (3-methyl-1,4-dioxido-2-quinoxalinyl)phenyl-収率 92%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a stirred suspension of 80 g. (0.59 mol.) of benzofurazan 1-oxide and 95 g. (0.59 mol.) of benzoylacetone in 1,000 ml. of ethanol was added 1.6 g. (0.04 mol.) of finely divided sodium hydroxide. The mixture became clear after about 30 minutes. Stirring was continued for a further 16 hours, and then the solid which had precipitated was collected by filtration. It was washed with ethanol, and dried to afford 153 g. (92% yield) of 2-benzoyl-3-methylquinoxaline 1,4-dioxide, m.p. 229°-231° C.

後処理

  1. additionTo a stirred suspension of 80 g
  2. waitwas continued for a further 16 hours
  3. customthe solid which had precipitated
  4. filtrationwas collected by filtration
  5. washIt was washed with ethanol
  6. customdried
  7. customto afford 153 g

出典と根拠

ORDレコード
ord-1ea22345cfc7476cadffd9fb63a59e86
出典データセット
uspto-grants-1977_03
特許番号
US04012385

関連ノート

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