Trifluoroacetic acid → 5-Chloro-2-(methylsulfanyl)-1-benzofuran-3(2H)-one

HRID 596905ノート

反応式

HRID 596905 の反応式
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([OH:14])=[C:6]([C:8](=[O:13])[CH2:9][S:10]([CH3:12])=O)[CH:7]=1.FC(F)(F)C(O)=O>C1C=CC=CC=1>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[O:14][CH:9]([S:10][CH3:12])[C:8](=[O:13])[C:6]=2[CH:7]=1

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 218282501-(5-Chloro-2-hydroxyphenyl)-2-(methanesulfinyl)ethan-1-one

生成物 1

HCID 214145205-Chloro-2-(methylsulfanyl)-1-benzofuran-3(2H)-one

試薬・触媒・溶媒 1

HCID 241Benzene溶媒

実験手順

5-Chloro-2-hydroxy-1-[(methylsulfinyl)acetyl]benzene (6.0 g) and trifluoroacetic acid (6 g) are refluxed in benzene (50 ml) for one hour under nitrogen. The solvent is removed under reduced pressure to give a yellow oil, which crystallizes on standing. Recrystallization from ethanol gives white crystals. (3.0 g 54%) m.p. 76°-78° C.

後処理

  1. customThe solvent is removed under reduced pressure
  2. customto give a yellow oil, which
  3. customcrystallizes
  4. customRecrystallization from ethanol
  5. customgives white crystals

出典と根拠

ORDレコード
ord-ba608b646d1049cbb2ebcba62c334e9e
出典データセット
uspto-grants-1977_03
特許番号
US04012422

反応ノート

読み込み中…