Aluminum(III) Chloride → 6,7-Dichloro-5-hydroxy-2,2-dimethyl-indan-1-one
反応式
[CH3:1][C:2]1([CH3:16])[CH2:10][C:9]2[C:4](=[C:5]([Cl:14])[C:6]([Cl:13])=[C:7]([O:11]C)[CH:8]=2)[C:3]1=[O:15].[Cl-].[Al+3].[Cl-].[Cl-]>CCCCCCC>[CH3:1][C:2]1([CH3:16])[CH2:10][C:9]2[C:4](=[C:5]([Cl:14])[C:6]([Cl:13])=[C:7]([OH:11])[CH:8]=2)[C:3]1=[O:15]参加物
4
実験手順
A stirred suspension of 2,2-dimethyl-5-methoxy-6,7-dichloro-1-indanone (12.2 g., 0.047 mole) and aluminum chloride (15.5 g., 0.116 mole) in heptane (500 ml.) is refluxed for 1 hour and cooled. The heptane is decanted from the reaction mixture and the solid residue is poured into ice (500 g.) and concentrated hydrochloric acid (50ml.). The product which separates (7.6 g.) melts at 273° C. after crystallization from nitromethane.
後処理
- temperatureis refluxed for 1 hour
- temperaturecooled
- customThe heptane is decanted from the reaction mixture
- additionthe solid residue is poured into ice (500 g.) and concentrated hydrochloric acid (50ml.)
- customafter crystallization from nitromethane
出典と根拠
- ORDレコード
- ord-73910ee7da494611b814eded18e97b15
- 出典データセット
- uspto-grants-1977_03
- 特許番号
- US04012524
反応ノート
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