Potassium Iodide → (1-Oxo-2-ethyl-6,7-dichloro-5-indanyloxy)acetonitrile

HRID 597014ノート

反応式

HRID 597014 の反応式
[CH2:1]([CH:3]1[CH2:11][C:10]2[C:5](=[C:6]([Cl:14])[C:7]([Cl:13])=[C:8]([OH:12])[CH:9]=2)[C:4]1=[O:15])[CH3:2].C(=O)([O-])[O-].[K+].[K+].Cl[CH2:23][C:24]#[N:25].[I-].[K+]>CC(C)=O>[O:15]=[C:4]1[C:5]2[C:10](=[CH:9][C:8]([O:12][CH2:23][C:24]#[N:25])=[C:7]([Cl:13])[C:6]=2[Cl:14])[CH2:11][CH:3]1[CH2:1][CH3:2]

参加物

6

反応物 4

HCID 4875Potassium IodideHCID 7856ChloroacetonitrileHCID 11430Potassium CarbonateHCID 128572202-Ethyl-5-hydroxy-6,7-dichloroindanone

生成物 1

HCID 12395624(1-Oxo-2-ethyl-6,7-dichloro-5-indanyloxy)acetonitrile

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

A mixture of 2-ethyl-5-hydroxy-6,7-dichloroindanone (24.5 g., 0.1 mole), anhydrous potassium carbonate (13.8 g., 0.10 mole), chloroacetonitrile (7.55 g., 0.10 mole) and potassium iodide (1.66 g.) in acetone (0.5 l.) is refluxed for 18 hours. The product which precipitates upon addition of water to the reaction mixture (20 g., 71%) melts at 139°-141° C. after recrystallization from butyl chloride.

後処理

  1. temperatureis refluxed for 18 hours
  2. customThe product which precipitates upon addition of water to the reaction mixture (20 g., 71%) melts at 139°-141° C.
  3. customafter recrystallization from butyl chloride

出典と根拠

ORDレコード
ord-2a35404037ff4b7db820cc8e602d7865
出典データセット
uspto-grants-1977_03
特許番号
US04012524

反応ノート

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