Chloroform → 1-(Bromomethyl)-4-chloro-2-nitrobenzene
反応式
[N+:1]([C:4]1[CH:11]=[C:10]([Cl:12])[CH:9]=[CH:8][C:5]=1[CH2:6]O)([O-:3])=[O:2].C(Cl)(Cl)Cl.P(Br)(Br)[Br:18]>O>[N+:1]([C:4]1[CH:11]=[C:10]([Cl:12])[CH:9]=[CH:8][C:5]=1[CH2:6][Br:18])([O-:3])=[O:2]参加物
5
実験手順
To a solution of 16.5 g. of 2-nitro-4-chlorobenzyl alcohol in 200 ml. of chloroform was added dropwise 13 g. of phosphorus tribromide, and the mixture was heated to reflux for 1 hour on a water bath. The reaction mixture was then poured into water, and the chloroform layer was separated and washed with water. After the solvent was removed, the residue was extracted with ligroin while warming and allowed to stand to form colorless acicular crystals of 2-nitro-4-chlorobenzyl bromide (80% yield) melting at 42° to 43° C.
後処理
- temperatureto reflux for 1 hour on a water bath
- customthe chloroform layer was separated
- washwashed with water
- customAfter the solvent was removed
- extractionthe residue was extracted with ligroin
- temperaturewhile warming
出典と根拠
- ORDレコード
- ord-a0537214ec96402ca5b697f29eb4e3a1
- 出典データセット
- uspto-grants-1977_03
- 特許番号
- US04013639
反応ノート
読み込み中…