Hydrogen Peroxide → 4-((Chloromethyl)sulfonyl)phenol

温度

0 °C

150 g (about 1.1 moles) of sulfuryl chloride were added dropwise, at 20° to 25° C, to a mixture of 140 g (1 mole) of 4-methylmercaptophenol, 880 g of ethylene chloride, 0.5 ml of concentrated sulfuric acid and 112 g (1.1 moles) of acetic anhydride. The mixture was stirred for a further hour at 40° to 45° C and a vigorous stream of air was then blown through the reaction solution for 10 minutes. After adding 0.5 g of sodium molybdate, 145 g of 50% strength hydrogen peroxide were added dropwise at 50° C. When the reaction had subsided, the batch was stirred for a further hour at 60° to 65° C; the excess peroxide was then destroyed with about 7 ml of 40% strength sodium bisulfite solution. Thereafter, a solution of 160 g (4 moles) of sodium hydroxide in 400 ml of water was added to the reaction mixture, which was kept below 50° C. The reaction of the mixture was then allowed to finish without cooling. The mixture was stirred for a further hour at 55° to 60° C and then cooled to 0° C, and the sodium phenolate which had precipitated was filtered off. It was dissolved in about 500 ml of water and aqueous hydrochloric acid was added until the mixture reacted strongly acid. After crystallization the product was filtered off and 167 g (81% of theory) of 4-chloromethylsulfonylphenol were obtained in the form of a colorless powder of melting point 110° C. ##STR33##

1. additionwere added dropwise at 50° C
2. stirringthe batch was stirred for a further hour at 60° to 65° C
3. customthe excess peroxide was then destroyed with about 7 ml of 40% strength sodium bisulfite solution
4. customwas kept below 50° C
5. customThe reaction of the mixture
6. temperaturewithout cooling
7. stirringThe mixture was stirred for a further hour at 55° to 60° C
8. customthe sodium phenolate which had precipitated
9. filtrationwas filtered off
10. dissolutionIt was dissolved in about 500 ml of water
11. additionaqueous hydrochloric acid was added until the mixture
12. customreacted strongly acid
13. customAfter crystallization the product
14. filtrationwas filtered off

ORDレコード

ord-c7c24b3d25db4c51972963a4f59179e4

出典データセット

uspto-grants-1977_03

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US04013794