Hydrazine hydrate (1:1) → 3,5-Diphenyl-4-methylpyrazoline

HRID 597583

反応式

HRID 597583 の反応式
O.[NH2:2][NH2:3].[CH3:4][C:5]([C:13]([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=O)=[CH:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1>CO.O>[C:7]1([C:6]2[NH:2][NH:3][CH:13]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[C:5]=2[CH3:4])[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1

参加物

5

反応物 2

HCID 24654Hydrazine hydrate (1:1)HCID 99812alpha-Methylchalcone

生成物 1

HCID 706390703,5-Diphenyl-4-methylpyrazoline収率 88.9%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 962Water溶媒

反応条件

温度
68 °C

実験手順

Isolated α-methylchalcone, 1.5 g (85% pure product by gas liquid chromatography) (0.00578 mole) is reacted with 0.55 g (0.008 mole) of 75% hydrazine hydrate in 7.5 ml of methanol and 1 ml of water under N2 at reflux (68° C) for 1 hour. Gas liquid chromatography shows the α-methylchalcone had reacted to form 3,5-diphenyl-4-methylpyrazoline.

後処理

  1. customhad reacted

出典と根拠

ORDレコード
ord-71f587f73c1b4fbb99d15de02474861f
出典データセット
uspto-grants-1977_03
特許番号
US04014896

関連ノート

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