Hydrochloric Acid → HCID 71293089、化合物

HRID 59766ノート

反応式

HRID 59766 の反応式
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[O:8][CH:7]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[CH3:18])[CH2:6][C:5]2=[O:19].O1CCCC1.B.Cl>O1CCCC1>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[O:8][CH:7]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[CH3:18])[CH2:6][CH:5]2[OH:19]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 2723981Borane;tetrahydrofuranHCID 71292849HCID 71292849、化合物

生成物 1

HCID 71293089HCID 71293089、化合物

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of 6-bromo-2-o-tolyl-chroman-4-one (11.0 g, 34.7 mmol) in tetrahydrofuran (100 ml) at room temperature a solution of borane tetrahydrofuran adduct (1M in tetrahydrofuran, 86.7 ml, 2.5 eq) was added dropwise. The solution was heated to reflux for 1 h, cooled to room temperature and added with caution to a mixture of ice water and 1N aqueous hydrochloric acid. The aqueous layer was extracted with dichloromethane, and the combined organic layers washed with water, dried with sodium sulfate and filtered and the solvent removed under reduced pressure. 6-Bromo-2-o-tolyl-chroman-4-ol was obtained as a yellow oil (11.1 g, 100%) and used in the reduction to the chroman without further purification.

後処理

  1. temperatureThe solution was heated
  2. temperatureto reflux for 1 h
  3. extractionThe aqueous layer was extracted with dichloromethane
  4. washthe combined organic layers washed with water
  5. dry with materialdried with sodium sulfate
  6. filtrationfiltered
  7. customthe solvent removed under reduced pressure

出典と根拠

ORDレコード
ord-50f4899f2c3e4382b04429ff14990598
出典データセット
uspto-grants-2016_09
特許番号
US09440941B2

反応ノート

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