Sulfuric Acid → 2-Hydroxyimino-2-(1-naphthyl)acetonitrile

HRID 597689

反応式

HRID 597689 の反応式
[C:1]1([CH2:11][C:12]#[N:13])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1.[OH-].[Na+].S(=O)(=O)(O)O.[N:21]([O-:23])=[O:22].[Na+]>CO.O>[N:21]([O:23][CH3:1])=[O:22].[OH:22][N:21]=[C:11]([C:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1)[C:12]#[N:13]

参加物

8

反応物 4

HCID 1118Sulfuric AcidHCID 85961-NaphthaleneacetonitrileHCID 14798Sodium HydroxideHCID 23668193Sodium Nitrite

生成物 2

HCID 12231Methyl nitriteHCID 736804482-Hydroxyimino-2-(1-naphthyl)acetonitrile収率 72.5%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒2 回HCID 962Water溶媒2 回

実験手順

2-(1-naphthyl)acetonitrile (16.7 g.) was added to a solution of sodium hydroxide (4.2 g.) in methanol (80 ml.). Gaseous methyl nitrite which was prepared by adding a solution of concentrated sulfuric acid (5 ml.) in water (10 ml.) to a solution of sodium nitrite (8.3 g.) in a mixture of methanol was introduced, under ice-cooling, and water (5 ml.). The mixture was stirred for 4 hours at the same temperature and the reaction mixture was treated by a conventional method to give 2-hydroxyimino-2-(1-naphthyl)acetonitrile (7.1 g.), oil.

後処理

  1. additionwas introduced, under ice-
  2. temperaturecooling
  3. additionthe reaction mixture was treated by a conventional method

出典と根拠

ORDレコード
ord-8f1c3c64db864963ae99b61fcf7561f3
出典データセット
uspto-grants-1977_03
特許番号
US04014915

関連ノート

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