Bromoacetyl bromide → 1-(Bromoacetyl)-1,2,3,4-tetrahydroquinoline

HRID 597705ノート

反応式

HRID 597705 の反応式
[Br:1][CH2:2][C:3](Br)=[O:4].[NH:6]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[CH2:9][CH2:8][CH2:7]1>C1C=CC=CC=1>[Br:1][CH2:2][C:3]([N:6]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[CH2:9][CH2:8][CH2:7]1)=[O:4]

参加物

4

反応物 2

HCID 61147Bromoacetyl bromideHCID 694601,2,3,4-Tetrahydroquinoline

生成物 1

HCID 5838141-(Bromoacetyl)-1,2,3,4-tetrahydroquinoline

試薬・触媒・溶媒 1

HCID 241Benzene溶媒2 回

実験手順

To a stirred solution of 20.2 g. of bromoacetyl bromide in 150 ml. of benzene is added dropwise over 30 minutes, 26.6 g. of 1,2,3,4-tetrahydroquinoline dissolved in 35 ml. of benzene. The reaction mixture is then stirred at room temperature for 18 hours, after which time the precipitate is filtered off. The resultant filtrate is washed successively with 1N HCL solution and with a saturated sodium chloride solution, dried, and the solvent removed under reduced pressure to yield 1-(bromoacetyl)-1,2,3,4-tetrahydroquinoline, b.p. 70°-80° C. (at 0.1 mm. Hg).

後処理

  1. filtrationafter which time the precipitate is filtered off
  2. washThe resultant filtrate is washed successively with 1N HCL solution and with a saturated sodium chloride solution
  3. customdried
  4. customthe solvent removed under reduced pressure

出典と根拠

ORDレコード
ord-ce6c420f2dd44392ad412c7d98e22342
出典データセット
uspto-grants-1977_03
特許番号
US04015005

反応ノート

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