Hydrochloric Acid → 4-(2-Phenyl-chroman-6-yloxy)-cyclohexanone

HRID 59773ノート

反応式

HRID 59773 の反応式
O1[C:5]2([CH2:10][CH2:9][CH:8]([O:11][C:12]3[CH:13]=[C:14]4[C:19](=[CH:20][CH:21]=3)[O:18][CH:17]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[CH2:16][CH2:15]4)[CH2:7][CH2:6]2)[O:4]CC1.Cl>O1CCCC1.C(OCC)(=O)C>[C:22]1([CH:17]2[CH2:16][CH2:15][C:14]3[C:19](=[CH:20][CH:21]=[C:12]([O:11][CH:8]4[CH2:9][CH2:10][C:5](=[O:4])[CH2:6][CH2:7]4)[CH:13]=3)[O:18]2)[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=1

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 903901236-(1,4-Dioxa-spiro[4.5]dec-8-yloxy)-2-phenyl-chroman

生成物 1

HCID 903901554-(2-Phenyl-chroman-6-yloxy)-cyclohexanone収率 94.4%

試薬・触媒・溶媒 2

HCID 8028Tetrahydrofuran溶媒HCID 8857Ethyl Acetate溶媒

実験手順

430 mg of 6-(1,4-dioxa-spiro[4.5]dec-8-yloxy)-2-phenyl-chroman were dissolved at room temperature in 5 ml of tetrahydrofuran. 5 ml of 10% aqueous hydrochloric acid were added and stirring at room temperature was continued for 16 h. The reaction mixture was diluted with ethyl acetate and the organic layer washed with saturated aqueous solution of sodium hydrogencarbonate. The organic layer was dried with sodium sulfate and filtered, and the volatile components removed under reduced pressure. 357 mg of the title compound were obtained as a pale yellow solid.

後処理

  1. washthe organic layer washed with saturated aqueous solution of sodium hydrogencarbonate
  2. dry with materialThe organic layer was dried with sodium sulfate
  3. filtrationfiltered
  4. customthe volatile components removed under reduced pressure

出典と根拠

ORDレコード
ord-95dbefce21d34803ba6c07ab62feab17
出典データセット
uspto-grants-2016_09
特許番号
US09440941B2

反応ノート

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