Chloride → Methyl 4-amino-3-nitrobenzoate

HRID 59803

反応式

HRID 59803 の反応式
[NH2:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][C:3]=1[N+:11]([O-:13])=[O:12].[Cl-].[CH3:15]O>>[CH3:15][O:7][C:6](=[O:8])[C:5]1[CH:9]=[CH:10][C:2]([NH2:1])=[C:3]([N+:11]([O-:13])=[O:12])[CH:4]=1

参加物

4

反応物 3

HCID 312ChlorideHCID 887MethanolHCID 74115Benzoic acid, 4-amino-3-nitro-

生成物 1

HCID 3941008Methyl 4-amino-3-nitrobenzoate収率 81%

実験手順

To a mixture of 4-amino-3-nitro-benzoic acid (10.0 g, 54.9 mmol) suspended in methanol (150 mL) was added thiony chloride (3.99 mL, 54.9 mmol). The mixture was heated to reflux overnight, then cooled to room temperature and filtered. The solid recovered by filtration was rinsed with cold methanol and dried to give 8.68 g (81%) of 4-amino-3-nitro-benzoic acid methyl ester.

後処理

  1. temperatureThe mixture was heated
  2. temperatureto reflux overnight
  3. filtrationfiltered
  4. filtrationThe solid recovered by filtration
  5. washwas rinsed with cold methanol
  6. customdried

出典と根拠

ORDレコード
ord-672a1d09152b4116b8e1310c6d95a876
出典データセット
uspto-grants-2016_09
特許番号
US09440956B2

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