Chloride → Methyl 4-amino-3-nitrobenzoate
反応式
[NH2:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][C:3]=1[N+:11]([O-:13])=[O:12].[Cl-].[CH3:15]O>>[CH3:15][O:7][C:6](=[O:8])[C:5]1[CH:9]=[CH:10][C:2]([NH2:1])=[C:3]([N+:11]([O-:13])=[O:12])[CH:4]=1参加物
4
実験手順
To a mixture of 4-amino-3-nitro-benzoic acid (10.0 g, 54.9 mmol) suspended in methanol (150 mL) was added thiony chloride (3.99 mL, 54.9 mmol). The mixture was heated to reflux overnight, then cooled to room temperature and filtered. The solid recovered by filtration was rinsed with cold methanol and dried to give 8.68 g (81%) of 4-amino-3-nitro-benzoic acid methyl ester.
後処理
- temperatureThe mixture was heated
- temperatureto reflux overnight
- filtrationfiltered
- filtrationThe solid recovered by filtration
- washwas rinsed with cold methanol
- customdried
出典と根拠
- ORDレコード
- ord-672a1d09152b4116b8e1310c6d95a876
- 出典データセット
- uspto-grants-2016_09
- 特許番号
- US09440956B2
反応ノート
読み込み中…