Acetic Acid → 5-methoxy-3-methyl-1H-quinazoline-2,4-dione
反応式
[CH3:1][O:2][C:3]1[CH:12]=[CH:11][CH:10]=[C:9]([NH:13][C:14]([NH:16][CH3:17])=[O:15])[C:4]=1[C:5](NC)=[O:6].[OH-].[Na+].C(O)(=O)C>O.C(O)C>[CH3:1][O:2][C:3]1[CH:12]=[CH:11][CH:10]=[C:9]2[C:4]=1[C:5](=[O:6])[N:16]([CH3:17])[C:14](=[O:15])[NH:13]2参加物
6
実験手順
A mixture of 2-Methoxy-N-methyl-6-[[(methylamino)carbonyl]amino]benzamide (200 mg, 0.843 mmol), 5% sodium hydroxide solution in water (8 ml) and ethanol (4 ml) was refluxed for 1 h. The solution was allowed to cool and then acidified with acetic acid. The aqueous solution was extracted with ethyl acetate. The extract was washed with brine, dried over magnesium sulfate, and concentrated under vacuum to afford 168 mg (97%) of the title compound.
後処理
- temperaturewas refluxed for 1 h
- temperatureto cool
- extractionThe aqueous solution was extracted with ethyl acetate
- washThe extract was washed with brine
- dry with materialdried over magnesium sulfate
- concentrationconcentrated under vacuum
出典と根拠
- ORDレコード
- ord-7be018ffceb44458a5f7a83ce0c4a6e1
- 出典データセット
- uspto-grants-2011_03
- 特許番号
- US07897607B2
反応ノート
読み込み中…