methyl 3-(2-chloro-6-fluorophenyl)-2-hydrazinylidene-3-oxopropanoate → Methyl 5-chloro-4-oxo-1,4-dihydrocinnoline-3-carboxylate
反応式
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4](F)[C:3]=1[C:9](=[O:17])[C:10](=[N:15][NH2:16])[C:11]([O:13][CH3:14])=[O:12]>COCCOCCOCCOC>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]2[C:3]=1[C:9](=[O:17])[C:10]([C:11]([O:13][CH3:14])=[O:12])=[N:15][NH:16]2参加物
3
反応条件
- 温度
- 140 °C
実験手順
A mixture of 4.2 g (16 mmol) of methyl 3-(2-chloro-6-fluorophenyl)-2-hydrazono-3-oxopropionate in 12 mL of triglyme was heated to 140° C. for 48 h. The slurry was then cooled to room temperature and the precipitate was collected by filtration. The precipitate was washed with diisopropyl ether and dried in vacuo to give 2.55 g (66%) of the title compound as a tan powder.
後処理
- temperatureThe slurry was then cooled to room temperature
- filtrationthe precipitate was collected by filtration
- washThe precipitate was washed with diisopropyl ether
- customdried in vacuo
出典と根拠
- ORDレコード
- ord-a772b97b19494f9aba28cd908cd5b0b6
- 出典データセット
- uspto-grants-2011_03
- 特許番号
- US07897607B2
反応ノート
読み込み中…