Sodium hydride → 5-Choro-4-oxo-1-(1-propylbutyl)-1,4-dihydroquinoline-3-carbonitrile
反応式
[Cl:1][C:2]1[CH:21]=[CH:20][CH:19]=[C:18](Cl)[C:3]=1[C:4](/[C:6](=[CH:9]/[NH:10][CH:11]([CH2:15][CH2:16][CH3:17])[CH2:12][CH2:13][CH3:14])/[C:7]#[N:8])=[O:5].[H-].[Na+]>O1CCOCC1>[Cl:1][C:2]1[CH:21]=[CH:20][CH:19]=[C:18]2[C:3]=1[C:4](=[O:5])[C:6]([C:7]#[N:8])=[CH:9][N:10]2[CH:11]([CH2:15][CH2:16][CH3:17])[CH2:12][CH2:13][CH3:14]参加物
4
反応条件
- 温度
- 100 °C
実験手順
(E)-2-(2,6-dichlorobenzoyl)-3-(1-propylbutylamino)acrylonitrile (0.020 g, 0.059 mmol) was dissolved in dioxane (2 mL). Sodium hydride (0.007 g, 0.18 mmol, 60% wt. dispersion in mineral oil) was added in one portion. Reaction was heated overnight at 100° C. Solution was cooled and quenched with MeOH and concentrated. Flash chromatography gave the desired product (0.007 g, 40%)