Hydrochloric Acid → HCID 24759348、化合物

HRID 598407ノート

反応式

HRID 598407 の反応式
[NH2:1][C:2]1[C:3]([NH:10][C:11]2[CH:16]=[CH:15][C:14]([I:17])=[CH:13][C:12]=2[F:18])=[CH:4][C:5](=[O:9])[N:6]([CH3:8])[CH:7]=1.[CH:19]1([S:22](Cl)(=[O:24])=[O:23])[CH2:21][CH2:20]1.Cl>N1C=CC=CC=1>[F:18][C:12]1[CH:13]=[C:14]([I:17])[CH:15]=[CH:16][C:11]=1[NH:10][C:3]1[C:2]([NH:1][S:22]([CH:19]2[CH2:21][CH2:20]2)(=[O:24])=[O:23])=[CH:7][N:6]([CH3:8])[C:5](=[O:9])[CH:4]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 2760919Cyclopropanesulfonyl chlorideHCID 58990848HCID 58990848、化合物

生成物 1

HCID 24759348HCID 24759348、化合物収率 79%

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

To a solution of 5-amino-4-(2-fluoro-4-iodophenylamino)-1-methylpyridin-2(1H)-one (62.3 mg, 0.174 mmol) in dry pyridine (3 mL) at 0° C. (ice-salt bath), was added cyclopropanesulfonyl chloride (29 mg, 0.206 mmol). The resultant reaction mixture was allowed to warm to room temperature and stirred for 16 hours. Aqueous HCl (1N) (5 mL) was added and the mixture stirred for 15 minutes, resulting in the formation of a precipitate which was isolated by filtration, dried under vacuum, to afford the desired compound as a tan solid. (64 mg, 79% yield)

後処理

  1. customThe resultant reaction mixture
  2. stirringthe mixture stirred for 15 minutes
  3. customresulting in the formation of a precipitate which
  4. customwas isolated by filtration
  5. customdried under vacuum

出典と根拠

ORDレコード
ord-7ee91f261ca74f35997615256b8b9a70
出典データセット
uspto-grants-2011_03
特許番号
US07897624B2

反応ノート

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