Hydrochloric Acid → HCID 178505403、化合物

HRID 598519

反応式

HRID 598519 の反応式
F[C:2]1[CH:8]=[C:7]([F:9])[C:6]([F:10])=[CH:5][C:3]=1[NH2:4].CCO[C:14]([S-:16])=[S:15].[K+].Cl>CN(C)C=O.O>[F:10][C:6]1[C:7]([F:9])=[CH:8][C:2]2[S:15][C:14]([SH:16])=[N:4][C:3]=2[CH:5]=1

参加物

6

反応物 3

HCID 313Hydrochloric AcidHCID 949532,4,5-TrifluoroanilineHCID 2735045Potassium ethylxanthate

生成物 1

HCID 178505403HCID 178505403、化合物収率 40%

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 6228Dimethylformamide溶媒

反応条件

温度
95 °C

実験手順

A mixture of 1 g (6.80 mmol) 2,4,5-trifluoroaniline and 1.33 g (8.16 mmol) potassium ethylxanthogenate in 5 mL dry N,N-dimethylformamide was heated in a 95° C. oil bath for 7 h. The reaction mixture was cooled to room temperature and diluted with water (15 mL). The mixture was acidified with aqueous HCl 2N. The precipitate was collected by filtration, washed with water and dried to provide 0.55 g (40%) of the titled compound as a light yellow solid. MS(m/e): 201.9 (M−H+).

後処理

  1. temperatureThe reaction mixture was cooled to room temperature
  2. filtrationThe precipitate was collected by filtration
  3. washwashed with water
  4. customdried

出典と根拠

ORDレコード
ord-8b9c6fe51079404f9f89c6c44a44a38b
出典データセット
uspto-grants-2011_03
特許番号
US07897627B2

関連ノート

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