Morpholine → 4-(4-Nitropyridin-2-yl)morpholine

HRID 598716

反応式

HRID 598716 の反応式
[N+:1]([C:4]1[CH:9]=[CH:8][N:7]=[CH:6][CH:5]=1)([O-:3])=[O:2].[NH:10]1[CH2:15][CH2:14][O:13][CH2:12][CH2:11]1>C1COCC1>[N+:1]([C:4]1[CH:9]=[CH:8][N:7]=[C:6]([N:10]2[CH2:15][CH2:14][O:13][CH2:12][CH2:11]2)[CH:5]=1)([O-:3])=[O:2]

参加物

4

反応物 2

HCID 8083MorpholineHCID 707344-Nitropyridine

生成物 1

HCID 574185464-(4-Nitropyridin-2-yl)morpholine収率 56.5%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of 2-chloro, 4-nitropyridine (0.2 g, 1.27 mmol) in THF (3 mL) was added morpholine (328 mg, 38.1 mmol). The reaction was heated to 80 C and stirred overnight. The solvent was evaporated and the residue purified by column chromatography (2/1 Hex/EtOAc) to yield 150 mg of the target compound.

後処理

  1. temperatureThe reaction was heated to 80 C
  2. customThe solvent was evaporated
  3. customthe residue purified by column chromatography (2/1 Hex/EtOAc)

出典と根拠

ORDレコード
ord-e456b857d97c47feae59f8a0e57888c7
出典データセット
uspto-grants-2011_03
特許番号
US07897599B2

関連ノート

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