Methyl iodide → 5-tert-Butyl-2-methoxy-1-methyl-3-nitro-benzene

HRID 598720ノート

反応式

HRID 598720 の反応式
[C:1]([C:5]1[CH:10]=[C:9]([N+:11]([O-:13])=[O:12])[C:8]([OH:14])=[C:7]([CH3:15])[CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[C:16]([O-])([O-])=O.[K+].[K+].CI>CC(C)=O>[C:1]([C:5]1[CH:10]=[C:9]([N+:11]([O-:13])=[O:12])[C:8]([O:14][CH3:16])=[C:7]([CH3:15])[CH:6]=1)([CH3:4])([CH3:3])[CH3:2]

参加物

5

反応物 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 574185474-tert-Butyl-2-methyl-6-nitro-phenol

生成物 1

HCID 213537455-tert-Butyl-2-methoxy-1-methyl-3-nitro-benzene収率 99%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

反応条件

温度
60 °C

実験手順

4-tert-Butyl-2-methyl-6-nitro-phenol (209 mg, 1 mmol) was dissolved in 3 mL acetone. 552 mg K2CO3 (4 eq) was added, followed by addition of MeI (0.33 mL, 5 mmol). The reaction mixture was stirred vigorously at 60° C. overnight. After removal of the acetone, the residue was shaken with DCM. Filtration and evaporation of the solution yielded 221 mg product which was used as such.

後処理

  1. customAfter removal of the acetone
  2. stirringthe residue was shaken with DCM
  3. filtrationFiltration and evaporation of the solution

出典と根拠

ORDレコード
ord-60b76187d62e4d6f8461cea5e16897e5
出典データセット
uspto-grants-2011_03
特許番号
US07897599B2

反応ノート

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