2-Aminothiazole → 2-(2-Chloro-4-fluorophenylsulfanyl)nitrobenzene

HRID 598977

反応式

HRID 598977 の反応式
[Cl:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[SH:9].F[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[N+:17]([O-:19])=[O:18].[Cl:20][C:21]1[CH:26]=[C:25]([F:27])[CH:24]=[CH:23][C:22]=1[S:28][C:29]1[CH:35]=[CH:34][CH:33]=[CH:32][C:30]=1[NH2:31].[NH2:36][C:37]1SC=[CH:40][N:41]=1>>[Cl:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[S:9][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[N+:17]([O-:19])=[O:18].[Cl:20][C:21]1[CH:26]=[C:25]([F:27])[CH:24]=[CH:23][C:22]=1[S:28][C:29]1[CH:35]=[CH:34][CH:33]=[CH:32][C:30]=1[NH:31][C:40]([NH:41][C:37]1[S:9][CH:3]=[CH:2][N:36]=1)=[O:18]

参加物

6

反応物 4

HCID 21552-AminothiazoleHCID 738951-Fluoro-2-nitrobenzeneHCID 5194462-Chloro-4-fluorothiophenolHCID 669982382-(2-Chloro-4-fluorophenylsulfanyl)aniline2 回

生成物 2

HCID 59732752N-[2-(2-Chloro-4-fluorophenylsulfanyl)phenyl]-N'-(thiazol-2-yl)urea収率 76%HCID 669989602-(2-Chloro-4-fluorophenylsulfanyl)nitrobenzene収率 80%

実験手順

2-(2-Chloro-4-fluorophenylsulfanyl)nitrobenzene (1.13 g, 80%) was prepared from 2-chloro-4-fluorothiophenol (0.89 g, 5.5 mmol) and 2-fluoronitrobenzene (0.71 g, 5.0 mmol) following the general procedure A. This compound was reduced to 2-(2-chloro-4-fluorophenylsulfanyl)aniline (0.76 g, 75%) following the general procedure B. N-[2-(2-Chloro-4-fluorophenylsulfanyl)phenyl]-N′-(thiazol-2-yl)urea (144 mg, 76%) was prepared from 2-(2-chloro-4-fluorophenylsulfanyl)aniline (126 mg, 0.5 mmol) and 2-aminothiazole (60 mg, 0.6 mmol) following the general procedure D.

出典と根拠

ORDレコード
ord-00e7ab67df424e3981dbb6018d64abce
出典データセット
uspto-grants-2011_03
特許番号
US07897628B2

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